Welcome to LncRNADisease v2.0

Posted by PKU & ECNU on May 10, 2018  • 

Long non-coding RNAs (lncRNAs) are an important category of non-coding RNAs (ncRNAs) which range from 200 nucleotides to multiple kilobases in length, with little or no protein-coding capacity. Circular RNAs (circRNAs) are widely expressed in diverse eukaryotic species and are characterized by covalently closed RNA loops through backsplicing events. Increasing evidence has highlighted the critical roles of lncRNAs and circRNAs in plenty of diseases development and progression. Here, we have updated the LncRNADisease database to version 2.0 by integrating comprehensive experimentally supported and predicted ncRNA-disease associations curated from manual literatures and other resources. The new developments in LncRNADisease v2.0 include (I) over 40-fold ncRNA-disease associations enhancement compare to the previous version; (II) integrating experimentally supported circRNA-disease associations; (III) providing regulatory relationship among ncRNA, mRNA and miRNA; (IV) mapping disease name to the Disease Ontology and Medical Subject Headings (MeSH); (V) providing a confidence score for each ncRNA-disease association.


Database Summary



Citation

Chen et al., LncRNADisease: a database for long-non-coding RNA-associated diseases. Nucleic Acids Res. 2013 Jan 1;41(D1):D983-6.

Bao et al., LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases. Nucleic Acids Res. 2019 Jan 8;47(D1):D1034-D1037.