RPRH is a database for predicted plant microRNA Functions in human. MicroRNAs are a class of small non-coding RNA molecules involved in gene expression regulation. Since the finding of cross-kingdom regulation of plant microRNA in 2012 by Zhang et al., increasing evidences suggest that microRNAs could affect gene expression in an inter-species manner. Here we developed the tool for predicting this kind of interactions between plant and human.

All plant microRNA information were downloaded from miRBase and human 3'UTR sequences were downloaded from UCSC. The target prediction of plant microRNA were based on TargetScan, miRanda and PITA. Functional gene sets used for enrichment analysis were obtain from MsigDB, GenesetDB and manual collecting. Experimental validated targets of human microRNA used for comparation of plant microRNA and human endogenous microRNA were obtained from miRTarBase. We appreciate all the databases mentioned above for providing resource to finish this work.

 

Related Links

miRBase:  http://www.mirbase.org/

UCSC:  http://genome.ucsc.edu/cgi-bin/hgTables

TargetScan:  http://www.targetscan.org/vert_72/

miRanda:  www.microrna.org/

PITA:  https://genie.weizmann.ac.il/pubs/mir07/mir07_data.html

MsigDB: http://software.broadinstitute.org/gsea/msigdb

GenesetDB:  https://genesetdb.auckland.ac.nz/haeremai.html

Paper:  https://doi.org/10.1016/j.cell.2018.03.035

miRTarBase:  http://mirtarbase.mbc.nctu.edu.tw/php/index.php