Entry Detail

General Information

Database ID: LDA0000013
Species: Homo sapiens
Confidence Score: 0.999893
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTAIRM1
Full Name:HOXA transcript antisense RNA, myeloid-specific 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS1|HOXA1-AS1|NCRNA00179
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27096094End Site(bp):27100258
External Links:
Ensembl ID:ENSG00000233429
Ensembl Transcript ID:N/A
Entrez Gene:100506311.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:20   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Glioblastoma  (Score: 0.999893)
Ovarian Neoplasms  (Score: 0.985791)
Thyroid Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3908D002289
Disease Name:lung non-small cell carcinomaCarcinoma, Non-Small-Cell Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Alias:NSCLC//Non-small cell lung cancer//non-small cell lung carcinomaCarcinoma, Non-Small-Cell Lung//Carcinoma, Non Small Cell Lung//Carcinomas, Non-Small-Cell Lung//Lung Carcinoma, Non-Small-Cell//Lung Carcinomas, Non-Small-Cell//Non-Small-Cell Lung Carcinomas//Non-Small-Cell Lung Carcinoma//Non Small Cell Lung Carcinoma//Carcinoma, Non-Small Cell Lung//Non-Small Cell Lung Carcinoma//Non-Small Cell Lung Cancer//Nonsmall Cell Lung Cancer

 

Disease Association Statistics

Total Associated ncRNA Number:545   
More Information
Causal ncRNA Number:468
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 1)
MALAT1  (Score: 1)
hsa_circ_0020123  (Score: 1)
hsa_circ_0016760  (Score: 1)
hsa_circ_0007385  (Score: 1)
DANCR  (Score: 1)
CCAT1  (Score: 1)
DLX6-AS1  (Score: 1)
AFAP1-AS1  (Score: 1)
SNHG3  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//FISH//IF//Luciferase Report Assay//IP//Invasion Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33537917
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:NSCLC tissues cells or exosomes
Dysfunction Pattern:Interaction(miR-498/ABCE1 axis)
Validated Method:In Vivo Experiment//Western Blot//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Invasion Assay//Transwell Assay
Description:HOTAIRM1 expression was dramatically upregulated, whereas miR-498 expression was significantly downregulated in NSCLC tissues cells or exosomes as compared to control groups. Functionally, HOTAIRM1 functioned as a sponge of miR-498 and miR-498 targeted ABCE1. In addition, HOTAIRM1 silencing inhibited NSCLC growth in vivo by downregulating ABCE1 and upregulating miR-498 expression.
Causality:Yes
Causal Description:Mechanistically, HOTAIRM1 knockdown repressed cell viability, migration, invasion and glycolysis metabolism, whereas induced cell apoptosis in NSCLC; however, miR-498 inhibitor hindered these effects.
Clinical-realted Application:

[2] PubMed ID:31880484
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:cancerous and paracancerous tissues of NSCLC
Dysfunction Pattern:Expression[Expression[Expression[highly expressed]-expression]-expression]
Validated Method:qRT-PCR
Description:LncRNA-HOTAIRM1 showed varied expression levels in different malignant tumor cell lines. There was a significant association between the expression of HOTAIRM1 and histopathological differentiation, tumor size, tumor/node/metastasis (TNM) stage, and Ki-67 of NSCLC patients. In addition, the relative expression of HOTAIRM1 in NSCLC tissues was significantly higher when compared with the individual patients' matched paracancerous tissues.
Causality:No
Causal Description:
Clinical-realted Application:Our study indicated there was a significant association between the expression of HOTAIRM1 and histopathological differentiation, tumor size, TNM stage, and Ki-67 of NSCLC patients, but not in gender, age, histology, lymph node metastasis state, and smoking history. Moreover, patients with high expression of HOTAIRM1 have shorter OS compared to the patients with high expression of HOTAIRM1.

[3] PubMed ID:36153414
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:exosomes
Dysfunction Pattern:Expression(highly expressed)
Validated Method:Migration Assay//FISH//qRT-PCR//Luciferase Report Assay//IP//Invasion Assay//IF
Description:The expression of lnc HOTAIRM1 (HOTAIRM1) in exosomes secreted by NSCLC tissues increased. After exosomal HOTAIRM1 entered CAFs, HOTAIRM1 can adsorb miR-328-5p to up-regulate the expression of SPON2 in CAFs. Up-regulation of SPON2 in CAFs could promote the migration and invasion of NSCLC cells.
Causality:No
Causal Description:
Clinical-realted Application: