Entry Detail

General Information

Database ID: LDA0000012
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTAIRM1
Full Name:HOXA transcript antisense RNA, myeloid-specific 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS1|HOXA1-AS1|NCRNA00179
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27096094End Site(bp):27100258
External Links:
Ensembl ID:ENSG00000233429
Ensembl Transcript ID:N/A
Entrez Gene:100506311.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:20   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Glioblastoma  (Score: 0.999893)
Ovarian Neoplasms  (Score: 0.985791)
Thyroid Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1612D001943
Disease Name:breast cancerBreast Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A thoracic cancer that originates in the mammary gland.Tumors or cancer of the human BREAST.
Alias:breast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary tumor//primary breast cancerBreast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

 

Disease Association Statistics

Total Associated ncRNA Number:593   
More Information
Causal ncRNA Number:383
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 1)
H19  (Score: 1)
GAS5  (Score: 1)
MALAT1  (Score: 1)
circRPPH1  (Score: 1)
CDKN2B-AS1  (Score: 1)
DANCR  (Score: 1)
SNHG1  (Score: 1)
SNHG7  (Score: 1)
MILIP  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot//Cell Viability Assay//Migration Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35694102
Disease Name:Breast Neoplasms
Sample:breast cancer cells and patients
Dysfunction Pattern:Regulation(SYN2 )
Validated Method:qRT-PCR//Migration Assay//Cell Viability Assay//Western Blot
Description:Results from univariate and multivariate Cox regression showed that SYN2, HOTAIRM1, BCAS1, and ALDOC were significantly associated with patient prognosis. Results from in vitro experiments showed that knockdown HOTAIRM1 expression promoted breast cancer cells proliferation, clone formation, and invasion. Up-regulation of HOTAIRM1 inhibited breast cancer cells proliferation, clone formation, and invasion.
Causality:Yes
Causal Description:Results from in vitro experiments showed that knockdown HOTAIRM1 expression promoted breast cancer cells proliferation, clone formation, and invasion. Up-regulation of HOTAIRM1 inhibited breast cancer cells proliferation, clone formation, and invasion.
Clinical-realted Application:Results from univariate and multivariate Cox regression showed that SYN2, HOTAIRM1, BCAS1, and ALDOC were significantly associated with patient prognosis. Immunohistochemistry and quantitative real-time polymerase chain reaction (qRT-PCR) results showed that the expression levels of SYN2 and HOTAIRM1 were negatively correlated with BRCA stage, whereas those of BCAS1 and ALDOC were positively correlated with BRCA stage.