Entry Detail

General Information

Database ID: LDA0000011
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTAIRM1
Full Name:HOXA transcript antisense RNA, myeloid-specific 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS1|HOXA1-AS1|NCRNA00179
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27096094End Site(bp):27100258
External Links:
Ensembl ID:ENSG00000233429
Ensembl Transcript ID:N/A
Entrez Gene:100506311.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:20   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Glioblastoma  (Score: 0.999893)
Ovarian Neoplasms  (Score: 0.985791)
Thyroid Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10534D013274
Disease Name:stomach cancerStomach Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the stomach.Tumors or cancer of the STOMACH.
Alias:gastric cancer//gastric neoplasmStomach Neoplasms//Neoplasm, Stomach//Stomach Neoplasm//Neoplasms, Stomach//Gastric Neoplasms//Gastric Neoplasm//Neoplasm, Gastric//Neoplasms, Gastric//Cancer of Stomach//Stomach Cancers//Gastric Cancer//Cancer, Gastric//Cancers, Gastric//Gastric Cancers//Stomach Cancer//Cancer, Stomach//Cancers, Stomach//Cancer of the Stomach//Gastric Cancer, Familial Diffuse

 

Disease Association Statistics

Total Associated ncRNA Number:824   
More Information
Causal ncRNA Number:522
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 1)
HOXA11-AS  (Score: 1)
HCP5  (Score: 1)
HCG18  (Score: 1)
H19  (Score: 1)
MALAT1  (Score: 1)
circHIPK3  (Score: 1)
CYTOR  (Score: 1)
AFAP1-AS1  (Score: 1)
OIP5-AS1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30302796
Disease Name:Stomach Neoplasms
Sample:gastric cancer tissues,cell lines
Dysfunction Pattern:Regulation[miR-17-5p/ PTEN axis]
Validated Method:Western Blot//Wound Healing Assay//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Microarray
Description: HOTAIRM1 and phosphatase and tensin homolog (PTEN) were both downregulated in GC, whereas miR-17-5p was upregulated.Moreover, the PI3K/AKT pathway was found activated in GC. HOTAIRM1 targeted miR-17-5p, whereas PTEN was the downstream target gene of miR-17-5p.
Causality:Yes
Causal Description:HOTAIRM1 suppressed proliferation and migration of GC cell line and induced their apoptosis, whereas miR-17-5p played the opposite role on GC cell line. HOTAIRM1 also postponed tumor growth in vivo and inhibited the PI3K/AKT pathway in GC.
Clinical-realted Application: