Entry Detail

General Information

Database ID: LDA0000010
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTTIP
Full Name:HOXA distal transcript antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS6|HOXA13-AS1|NCRNA00213
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27200421End Site(bp):27207259
External Links:
Ensembl ID:ENSG00000243766
Ensembl Transcript ID:N/A
Entrez Gene:100316868.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:19   
More Information
Causal Disease Number:15
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Glioma  (Score: 0.731059)
Retinoblastoma  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Nasopharyngeal Neoplasms  (Score: 0.731059)
Arthritis, Rheumatoid  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D008171
Disease Name:Lung Diseases
Category:MeSH
Type:Respiratory Tract Diseases
Define:Pathological processes involving any part of the LUNG.
Alias:Lung Diseases//Disease, Lung//Diseases, Lung//Lung Disease//Pulmonary Disease//Disease, Pulmonary//Diseases, Pulmonary//Pulmonary Diseases

 

Disease Association Statistics

Total Associated ncRNA Number:1   
More Information
Causal ncRNA Number:1
Network:
Top Causal ncRNAs:
HOTTIP  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//EdU Staining//IF
Weak Evidence:

 

Reference

[1] PubMed ID:34212978
Disease Name:Lung Diseases
Sample:A549 cells and Lung tissues of mouse model
Dysfunction Pattern:Interaction(miR‑744‑5p/PTBP1 signaling axis)
Validated Method:In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//qRT-PCR//Luciferase Report Assay//EdU Staining//IF
Description:The results of the present study revealed that the proliferation and migration of A549 cells were both suppressed following the knockdown of HOTTIP. The lncRNA HOTTIP was found to target and downregulate the expression levels of miR‑744‑5p. Furthermore, miR‑744‑5p targeted and downregulated the expression levels of PTBP1.
Causality:Yes
Causal Description:The knockdown of lncRNA HOTTIP expression also relieved the fibrosis of the lung tissues of mice.
Clinical-realted Application: