Entry Detail

General Information

Database ID: LDA0000008
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTTIP
Full Name:HOXA distal transcript antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS6|HOXA13-AS1|NCRNA00213
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27200421End Site(bp):27207259
External Links:
Ensembl ID:ENSG00000243766
Ensembl Transcript ID:N/A
Entrez Gene:100316868.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:19   
More Information
Causal Disease Number:15
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Glioma  (Score: 0.731059)
Retinoblastoma  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Nasopharyngeal Neoplasms  (Score: 0.731059)
Arthritis, Rheumatoid  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D009062
Disease Name:Mouth Neoplasms
Category:MeSH
Type:Neoplasms
Define:Tumors or cancer of the MOUTH.
Alias:Mouth Neoplasms//Mouth Neoplasm//Neoplasm, Mouth//Neoplasms, Oral//Neoplasm, Oral//Oral Neoplasm//Oral Neoplasms//Neoplasms, Mouth//Cancer of Mouth//Mouth Cancers//Oral Cancer//Cancer, Oral//Cancers, Oral//Oral Cancers//Cancer of the Mouth//Mouth Cancer//Cancer, Mouth//Cancers, Mouth

 

Disease Association Statistics

Total Associated ncRNA Number:15   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
H19  (Score: 0.999893)
FGD5-AS1  (Score: 0.985791)
HOTTIP  (Score: 0.731059)
HOXA10-AS  (Score: 0.731059)
ELDR  (Score: 0.731059)
DLEU2  (Score: 0.731059)
ADAMTS9-AS1-202  (Score: 0.731059)
PTCSC3  (Score: 0.731059)
circVAPA  (Score: 0.731059)
hsa_circ_102450  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Transfection//Wound Healing Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34268933
Disease Name:Mouth Neoplasms
Sample:oral cancer tissues
Dysfunction Pattern:Interaction(miR-206)
Validated Method:qRT-PCR//Transfection//Wound Healing Assay//Transwell Assay
Description:HOTTIP was abnormally increased in oral cancer. Besides, when HOTTIP was knocked down in oral cancer cell lines, miR-206-206 was remarkably up-regulated. Dual-luciferase reporter gene experiment confirmed the binding relationship between miR-206 and HOTTIP.
Causality:Yes
Causal Description:The results of cell functional experiments found that HOTTIP played a role in promoting tumor proliferation and migration in oral cancer cells. B
Clinical-realted Application:At the same time, the survival analysis showed that the higher expression of HOTTIP was significantly correlated with a shorter overall survival.