Entry Detail

General Information

Database ID: LDA0000007
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTTIP
Full Name:HOXA distal transcript antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS6|HOXA13-AS1|NCRNA00213
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27200421End Site(bp):27207259
External Links:
Ensembl ID:ENSG00000243766
Ensembl Transcript ID:N/A
Entrez Gene:100316868.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:19   
More Information
Causal Disease Number:15
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Glioma  (Score: 0.731059)
Retinoblastoma  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Nasopharyngeal Neoplasms  (Score: 0.731059)
Arthritis, Rheumatoid  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:7148D001172
Disease Name:rheumatoid arthritisArthritis, Rheumatoid
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Alias:Arthritis or polyarthritis, rheumatic//atrophic ArthritisArthritis, Rheumatoid//Rheumatoid Arthritis

 

Disease Association Statistics

Total Associated ncRNA Number:67   
More Information
Causal ncRNA Number:32
Network:
Top Causal ncRNAs:
GAS5  (Score: 1)
NEAT1  (Score: 1)
LINC00638  (Score: 0.999893)
THRIL  (Score: 0.999893)
CASC2  (Score: 0.985791)
ZFAS1  (Score: 0.985791)
MEG3  (Score: 0.985791)
HOTTIP  (Score: 0.731059)
HOTAIR  (Score: 0.731059)
HAND2-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:34808131
Disease Name:Arthritis, Rheumatoid
Sample:rheumatoid arthritis synovial fibroblasts
Dysfunction Pattern:Interaction(miR-1908-5p/STAT3 axis)
Validated Method:In Vivo Experiment//Western Blot//Flow Cytometry//qRT-PCR//Luciferase Report Assay//H&E Staining//ELISA
Description:We found that HOTTIP was upregulated in rheumatoid arthritis synovial fibroblasts (RASFs).HOTTIP directly bound to miR-1908-5p and negatively modulated miR-1908-5p expression while positively regulating STAT3.
Causality:Yes
Causal Description: In addition, in vivo experiments demonstrated that overexpression of HOTTIP aggravated inflammation in RA mice, which was demonstrated by hematoxylin and eosin (HE) staining and the increased expression levels of CD4+ interleukin (IL)-17+, forkhead Box P3 (FOXP3) and retinoid-related orphan receptor gamma-t (RORγt)
Clinical-realted Application: