Entry Detail

General Information

Database ID: LDA0000006
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTTIP
Full Name:HOXA distal transcript antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS6|HOXA13-AS1|NCRNA00213
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27200421End Site(bp):27207259
External Links:
Ensembl ID:ENSG00000243766
Ensembl Transcript ID:N/A
Entrez Gene:100316868.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:19   
More Information
Causal Disease Number:15
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Glioma  (Score: 0.731059)
Retinoblastoma  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Nasopharyngeal Neoplasms  (Score: 0.731059)
Arthritis, Rheumatoid  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D009303
Disease Name:Nasopharyngeal Neoplasms
Category:MeSH
Type:Neoplasms
Define:Tumors or cancer of the NASOPHARYNX.
Alias:Nasopharyngeal Neoplasms//Nasopharyngeal Neoplasm//Neoplasm, Nasopharyngeal//Neoplasms, Nasopharyngeal//Nasopharynx Neoplasms//Nasopharynx Neoplasm//Neoplasm, Nasopharynx//Neoplasms, Nasopharynx//Cancer of Nasopharynx//Nasopharynx Cancers//Nasopharyngeal Cancer//Cancer, Nasopharyngeal//Cancers, Nasopharyngeal//Nasopharyngeal Cancers//Nasopharynx Cancer//Cancer, Nasopharynx//Cancers, Nasopharynx//Cancer of the Nasopharynx

 

Disease Association Statistics

Total Associated ncRNA Number:5   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
HOTTIP  (Score: 0.731059)
hsa_circ_0000615  (Score: 0.731059)
PCBP2-OT1  (Score: 0.731059)
PVT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30685769
Disease Name:Nasopharyngeal Neoplasms
Sample:NPC tissues
Dysfunction Pattern:Interaction[Inhibiting miR-4301 ]
Validated Method:CCK8//qRT-PCR//Transwell Assay
Description:HOTTIP expression was increased in NPC tissues.HOTTIP silencing suppressed the proliferation, cell cycle, migration, and invasion of NPC cells.
Causality:Yes
Causal Description:HOTTIP silencing suppressed the proliferation, cell cycle, migration, and invasion of NPC cells.
Clinical-realted Application:Higher levels of HOTTIP are correlated with lower survival in NPC patients.