Entry Detail

General Information

Database ID: LDA0000005
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTTIP
Full Name:HOXA distal transcript antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS6|HOXA13-AS1|NCRNA00213
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27200421End Site(bp):27207259
External Links:
Ensembl ID:ENSG00000243766
Ensembl Transcript ID:N/A
Entrez Gene:100316868.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:19   
More Information
Causal Disease Number:15
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Glioma  (Score: 0.731059)
Retinoblastoma  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Nasopharyngeal Neoplasms  (Score: 0.731059)
Arthritis, Rheumatoid  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5517
Disease Name:stomach carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A stomach cancer that is located_in the stomach.
Alias:cancer of the stomach//carcinoma of stomach//gastric carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:30   
More Information
Causal ncRNA Number:26
Network:
Top Causal ncRNAs:
GASAL1  (Score: 0.985791)
HOTTIP  (Score: 0.731059)
HEIH  (Score: 0.731059)
HCP5  (Score: 0.731059)
LIFR-AS1  (Score: 0.731059)
IUR  (Score: 0.731059)
lnc-LIFR-AS1  (Score: 0.731059)
DSCAM-AS1  (Score: 0.731059)
CASC2  (Score: 0.731059)
BCYRN1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32633359
Disease Name:stomach carcinoma
Sample:cell lines MGC-803, HGC-27, SNU-1, and SGC-7901
Dysfunction Pattern:regulation[adsorbing miR-615-3p]
Validated Method:CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay
Description: LncRNA HOTTIP was highly expressed in gastric carcinoma cell lines MGC-803, HGC-27, SNU-1, and SGC-7901 than in normal gastric mucosa cell line RGM-1.It affects cell proliferation and apoptosis in gastric carcinoma by adsorbing miR-615-3p via a sponge effect.
Causality:Yes
Causal Description: After knockdown of lncRNA HOTTIP, the proliferation function of gastric carcinoma cells was markedly weakened, and the proportion of apoptotic cells increased.
Clinical-realted Application: