Entry Detail

General Information

Database ID: LDA0000003
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTTIP
Full Name:HOXA distal transcript antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS6|HOXA13-AS1|NCRNA00213
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27200421End Site(bp):27207259
External Links:
Ensembl ID:ENSG00000243766
Ensembl Transcript ID:N/A
Entrez Gene:100316868.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:19   
More Information
Causal Disease Number:15
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Glioma  (Score: 0.731059)
Retinoblastoma  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Nasopharyngeal Neoplasms  (Score: 0.731059)
Arthritis, Rheumatoid  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005910
Disease Name:Glioma
Category:MeSH
Type:Neoplasms
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:Glioma//Gliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

 

Disease Association Statistics

Total Associated ncRNA Number:330   
More Information
Causal ncRNA Number:303
Network:
Top Causal ncRNAs:
HOXA11-AS  (Score: 1)
FOXD2-AS1  (Score: 1)
H19  (Score: 1)
GAS5  (Score: 1)
PVT1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
MEG3  (Score: 1)
HCG11  (Score: 1)
HOXA-AS2  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:Transfection//Migration Assay//qRT-PCR//MTT//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:35402278
Disease Name:Glioma
Sample:SF268 cells
Dysfunction Pattern:Interaction(miRNA-10b/Zeb1/Zeb2)
Validated Method:Transfection//Migration Assay//qRT-PCR//MTT//ELISA
Description:lncRNA HOTTIP was found to be particularly elevated in SF268 cells and over-expression of HOTTIP in both A172 and LN229 remarkably increased their TMZ IC-50s, along with increased cell proliferation, migration, clonogenicity and markers of angiogenesis and metastasis. As a mechanism we observed increased expression of miRNA-10b and mesenchymal markers Zeb1/Zeb2 and reduced expression of E-cadherin in SF268 cells indicating a role of EMT in TMZ resistance. A172 and LN229 cells with overexpressed HOTTIP also had similarly induced EMT and the elevated miR-10b levels. Further, silencing of miR-10b in HOTTIP overexpressing cells as well as the SF268 cells reversed EMT with associated sensitization of all the tested cells to TMZ.
Causality:Yes
Causal Description:lncRNA HOTTIP was found to be particularly elevated in SF268 cells and over-expression of HOTTIP in both A172 and LN229 remarkably increased their TMZ IC-50s, along with increased cell proliferation, migration, clonogenicity and markers of angiogenesis and metastasis.
Clinical-realted Application: