Entry Detail

General Information

Database ID: LDA0000002
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTTIP
Full Name:HOXA distal transcript antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS6|HOXA13-AS1|NCRNA00213
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27200421End Site(bp):27207259
External Links:
Ensembl ID:ENSG00000243766
Ensembl Transcript ID:N/A
Entrez Gene:100316868.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:19   
More Information
Causal Disease Number:15
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Glioma  (Score: 0.731059)
Retinoblastoma  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Nasopharyngeal Neoplasms  (Score: 0.731059)
Arthritis, Rheumatoid  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3347D012516
Disease Name:osteosarcomaOsteosarcoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A bone sarcoma that is located_in bone that has_material_basis_in cells of mesenchymal origin.A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Alias:Osteogenic sarcoma//Skeletal sarcoma//bone tissue neoplasm//osteoid sarcomaOsteosarcoma//Osteosarcomas//Osteosarcoma Tumor//Osteosarcoma Tumors//Tumor, Osteosarcoma//Tumors, Osteosarcoma//Sarcoma, Osteogenic//Osteogenic Sarcomas//Sarcomas, Osteogenic//Osteogenic Sarcoma

 

Disease Association Statistics

Total Associated ncRNA Number:328   
More Information
Causal ncRNA Number:300
Network:
Top Causal ncRNAs:
MALAT1  (Score: 1)
SNHG16  (Score: 1)
PVT1  (Score: 1)
UCA1  (Score: 1)
TUG1  (Score: 1)
NEAT1  (Score: 1)
KCNQ1OT1  (Score: 1)
GAS5  (Score: 1)
LINC00662  (Score: 1)
ZFAS1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Wound Healing Assay//CCK8//qRT-PCR//RIP
Weak Evidence:

 

Reference

[1] PubMed ID:33475442
Disease Name:Osteosarcoma
Sample:OS tissues
Dysfunction Pattern:Interaction(PTBP1/KHSRP )
Validated Method:qRT-PCR//RIP
Description:Our data demonstrated HOTTIP was upregulated in OS tissues. In mechanism, PTBP1 and KHSRP highly expressed in OS and HOTTIP was identified to interact with PTBP1 to promote KHSRP expression. Meanwhile, we found that overexpression of KHSRP or PTBP1, individually, can partially remove the repression of HOTTIP suppression for OS cell progression.
Causality:Yes
Causal Description:HOTTIP knockdown resulted in a suppression of OS cell proliferation, invasion and migration, as well as a promotion of OS cell apoptosis, while HOTTIP overexpression exhibited opposite effects.
Clinical-realted Application:

[2] PubMed ID:31423232
Disease Name:Osteosarcoma
Sample:OS tissues and cell lines
Dysfunction Pattern:Interaction[c-Myc]
Validated Method:CCK8//qRT-PCR//Wound Healing Assay//Western Blot
Description:HOTTIP was demonstrated to be upregulated in OS tissues and cell lines.HOTTIP promoted cell migration and invasion by upregulating c-Myc in OS. The positive feedback loop formed by HOTTIP and c-Myc may contribute to OS progression, and HOTTIP may act as a therapeutic target for OS.
Causality:Yes
Causal Description:knockdown of HOTTIP inhibited OS cell migration, invasion and EMT, and suppressed c-Myc expression. In addition, overexpression of c-Myc increased HOTTIP expression and enhanced OS cell migration and invasion.
Clinical-realted Application: